Exercise may be the single most potent medical intervention ever known

It's long been believed that execise works well to maintain or promote good health. It seemed epidemiologically true. But little is known as for its basic mechanism. Recently, there have been a lot of research papers published as for the effects of exercise to health/diseases covering genomics, proteomics, tissue level and individual cases. 

It is a program with the title MoTrPAC, the acronym of Molecular Transducers of Physical Activity Consortium. The web site of this program is here;https://www.motrpac.org/. You may see what a large aspects of research work it is covering and get its bibliography. 

I haven't read through the bibliography yet, too vast area of topics. Here is an interview to one of the organizers, Euan Ashley, a chair professor in Stanford University, a cardiologist, by Eric Topol, a famous researcher in Scripps Lab organizing this site "Ground Truths".

https://erictopol.substack.com/p/evan-ashley-exercise-may-be-the-single

Prof. Ashley and Topol make only general discusssion about how exercise works to improve health or prevent diseases. Still very inspiring and worth reading it through. 

What made me impressed at this program is that they have investigated about the topic in basic genom/protein level. It has revealed all tissues undergo remarkable changes. Exposure to low dosis of stressor;exercise potentially induces a stimulatory effect; hormesis. In multipe tissues, heat shock response is caused by exercise. Heat shock protein is prominent part of the stress response to exercise. Among all the tissues/organs like heart, lung, immune system or small intestine, adrenal gland is one of the most changed organ. At cellular level, repair mechanism is the main response to exercise and does preventive benefit against diseases.  

Higher intensity of exercise makes more benefit. One minute exercise gives us 5 minute extralife. One minute high intensity exercise 7 to 8 minute extralife. 

If exerecise is of low intensity, continuing it makes beneficial effects. 

These findings are not just historical legends among people but have been proved by epidemiology, genomics, biochemistry and physiology now. Why staying sedentary on chair all day? Start sessions of light exercise indoor and, if possible, moderate to strenuous one outdoor. It will keep you young and healthy.

It is what I am telling to myself!