I was excited as well as attracted by a couple of articles published in Science lately. They were regarding the function of type I interferon in the innate immunity. Genetic dysfunctions of type I interferon or the autoimmune mechanism against type I interferon predisposes severity in COVID19 infection as they say, even if they won't explain all of those severe cases. There must be multiple factors responsible for exacerbation of the cases.
https://science.sciencemag.org/content/early/2020/09/25/science.abd4570
https://science.sciencemag.org/content/early/2020/09/23/science.abd4585
It still seems to indicate the innate immunity plays an important role in defense mechanism for this virus infection. It has been noted those having had vaccination against pathogens other than this SARS CoV 2 may be resistant to the virus and/or may be spared from aggravation. Vaccination, including BCG, is known to augment the innate immunity.
The innate immunity could be affected by the past history of the host for viral or other pathogens' infection. It could be genetically polymorphic and may explain the fact that certain race is more resistant to it.
This finding that the innate immunity is of importance for defense against SARS CoV 2 may let us understand the pathophysiology of this infection and helps to find out the treatment based on it. It may help to distinguish those being aggravated in the course from the others in the beginning of the course as well.
I could not help being excited to know of such findings as these. Let's hope researchers may achieve understanding fully the process of the infection. It is the only way to solve this pandemic.
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